#GRAPHPAD PRISM 5 SURVIVAL SOFTWARE#

Figure 3 shows the probability of death in the first year after RA diagnosis was 0.48% and at 10 years 8.16%. In the whole cohort there were 26 documented deaths cause of death could not be determined. The median time to first cardiovascular event from RA diagnosis was 2.53 years (range 0.02–8.31). The probability of a cardiovascular event in the first year after diagnosis of RA was 0.64% and 9.4% after 10 years. The time to first cardiovascular event is shown in Figure 2. Reliable data on non-steroidal anti-inflammatory drug (NSAID) use was unavailable. None of the patients were on biologics at the time of their event. Table 1 shows the use of rheumatoid and cardiovascular medications. The most common cardiovascular risk factors were smoking (41% current smokers, 35% ex-smokers) and hypertension (71%) 41% had a family history of ischemic heart disease and 12% had diabetes. There were no cardiac arrests or deaths during the study period. Of the 34 RA patients Palmatine who had cardiovascular events, the median age was 64 years (range 47–79) and there was an equal sex distribution ĩ1% were rheumatoid factor positive 59% of the cardiovascular events were non-ST elevation MI, 21% were ST elevation MI and 21% unstable angina. The median RA disease duration of the cohort as a whole was 5.8 years (i.e., in over half of cohort, RA diagnosis was made post-March 2002). A search of the Rheumatology Departmental database yielded 619 additional patients who were diagnosed with RA during the study period (who did not sustain Bioactive Compound Library a cardiovascular event) giving a total of 653 patients (Fig. 1, flowchart of patient selection). This was the first cardiovascular event following RA diagnosis in all 34 patients. One hundred and ninety-four of these had a confirmed cardiovascular event, of whom 34 were diagnosed with RA between January 1999 and December 2008 prior to their cardiovascular event. ICD9 or 10 codes for RA and a cardiovascular event. Four hundred and six patients were discharged during the study period with combined The rheumatology database case notes were also reviewed to see more confirm the presence or absence of a discharge diagnosis of ischemic heart disease to cross-check the accuracy and completeness of the ICD discharge coding search. RA diagnosis was made using American College of Rheumatology (ACR) criteria and/or rheumatologist diagnosis.

The denominator of all newly diagnosed RA patients within the 10-year study period, the vast majority seen as outpatients, was calculated from the Department of Rheumatology database. Kaplan–Meier survival analysis was performed to identify time from RA diagnosis to first cardiovascular event and time from RA diagnosis to death.

#GRAPHPAD PRISM 5 SURVIVAL SOFTWARE#

With graphpad prism 5 (GraphPad Software Inc., La Jolla, CA, USA).

Graphpad prism 5 survival